Neuromodulator (Botox®, Dysport®, Nuceiva®, Xeomine®), which are mostly botulinum toxin or neurotoxins, are substances injected into the skin which is known to weaken or paralyze muscles, and that can prevent wrinkles from developing or worsening. Although botulinum toxin is a life-threatening substance in nature, small doses — such as those used in the application of medical and cosmetic Botox — are considered safe.
Neuromodulators were originally approved for the restriction of rapid involuntary eye twitching, they were then discovered to have temporary effects on relaxing furrows and softening the appearance of lines in the skin. Also, neuromodulator injections were also found to relax the scalp muscles, thus relieving migraines.
Neuromodulator treatments are not a permanent solution for wrinkles and fine lines. The results are temporary and usually last about four to six months, gradually wearing off. Patients will need maintenance injections every 4 to 6 months to maintain the appearance.